FAS (Fas, CD95, and APO-1) is a 46kD transmembrane glycoprotein, which acts as a cell death receptor in the TNFR (tumor necrosis factor receptor) superfamily. FAS is also present in a soluble form, which weighs around 26kDa. You can know more about Anti-Fas Antibody Picoband online.

Fas recombinant antibody (Clone R-125224)-NP_000034.1

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Inducing FAS results in the aggregation of its intracellular Fas-associated death domains (FADD) as well as the creation of the death-inducing signals complex (DISC) and the activated caspases. 

FAS has been proven to stimulate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK. FAS is involved in transducing proliferating signals of normal diploid fibroblasts and T cells. At a minimum, eight alternatively spliced transcript variants that encode seven distinct isoforms have been identified. 

The isoforms that lack the transmembrane domain might negatively influence Apoptosis that is mediated by the full-length isoform. The Fas/Fas-ligand system has been demonstrated to be involved in many human diseases, including AIDS as well as hepatitis and cancer. 

It is also believed that the induction of apoptosis by the FAS ligand pathway is primarily associated with antiviral immune responses.

FAS Antibody (B-10) is a top-quality monoclonal antibody to FAS (also known as CD95 antibody or Fas cell surface death receptor antibody as well as TNFRSF6 antibody) that is suitable for the detection that the FAS protein is is of human origin. 

The FAS Antibody (B-10) is available in either the unconjugated anti-FAS antibody and also as multiple conjugated versions of the anti-FAS antibody. These include HRP, agarose, PE, FITC, and multiple Alexa Fluor(r) conjugates.